Oxprenolol

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Image:Oxprenolol.png
Oxprenolol
Systematic (IUPAC) name
1-propan-2-ylamino-3-(2 -prop-2-enoxyphenoxy)-propan-2-ol
Identifiers
CAS number	6452-71-7
ATC code	C07AA02
PubChem	4631
Chemical data
Formula	C15H23NO3
Mol. mass	265.348
Pharmacokinetic data
Bioavailability	20-70%
Metabolism	Hepatic
Half life	1-2hours
Excretion	Renal Lactic (In lactiferous females)
Therapeutic considerations
Pregnancy cat.	C(AU)
Legal status	℞ Prescription only
Routes	oral

Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris and abnormal heart rhythms. It is also used for treating high blood pressure.

Oxprenolol is an EXTREME Beta-Blocker and should on NO ACCOUNT be administered to ASTHMATICS under any circumstances - it is a prescribed drug that can cause irreversible airways failure/inflammation and is highly dangerous. Many deaths in Asthmatics have been attributed to mis-prescribing of this drug by GPs who had not undergone training in its use or had decided blockers were a preferable choice to other anxiolytics - this situation has since been rectified due to the number of deaths (this can be likened to the "wine deaths" of the late 1980s where Sulphites caused many deaths - interfering with the Beta2 adrenal system). In non-asthmatics its use is considered therapeutic.

Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol. (McDevitt 1987)

References

• McDevitt DG. Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs. Eur Heart J. 1987 Dec;8 Suppl M:9-14. Review. PMID 2897304.

v • d • e Beta blockers (C07)
Non-selective β antagonists (C07AA)	Metipranolol, Nadolol, Oxprenolol, Penbutolol, Pindolol, Propranolol, Timolol, Sotalol
β1 antagonists (cardioselective) (C07AB)	Atenolol, Acebutolol, Betaxolol, Bisoprolol, Esmolol, Metoprolol, Nebivolol
Mixed α1/β antagonists (C07AG)	Carvedilol, Labetalol

ru:Окспренолол

Wikipedia information about Oxprenolol This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Oxprenolol". It may not have been reviewed by professional editors (see full disclaimer). Help contribute to Americola and edit this article.