There are 23 episodes each in seasons one to three. The fourth season has started airing in the United States and Canada. The first episode of the fourth season was first aired in the United Kingdom on Sky One 22nd March 2007.
Detective Lilly Rush from Philadelphia Homicide reopens a 1976 murder case when a woman, dying of cancer, comes forward claiming to have been a witness.
The fiancé of a fireman asks Lilly to help prove that a convicted felon, about to be paroled on an unrelated crime, is responsible for the murder of the fireman's first wife.
Lilly re-investigates the 1990 case of a murdered church organist when his Alzheimer's-stricken widow begins having flashbacks of the night in question.
After a drug addict brings in an audio tape in which a fatal shooting is heard Lilly reopens a 1973 case involving the unsolved death of a young police officer murdered after responding to a call at a drug-infested housing project.
A petty crook hoping to get a reduced sentence, relates witnessing a young man washing blood out of his car the night a teen track runner was murdered.
After a woman emerges from a two-year coma with no memory of her identity or her daughter's death, the detectives investigate the fall in which the little girl died.
A college professor whose career ended in disgrace after being suspected of murdering one of his female students in 1995, offers new information regarding the case that he hopes will clear his name.
Rush and Valens re-open the case of a 25-year-old black woman, who was murdered in 1939, after the woman's granddaughter comes forward with new information.
The discovery of a body with several bullet holes at the site of a disco destroyed in a 1978 fire, of suspected arson leads Rush and Valens to re-investigate the circumstances of the fire.
Human remains found in the excavation for a new building lead Rush and Valens to investigate the unsolved deaths of a man and a woman in their mid-20's who disappeared in 1969.
When a 19-year-old girl turns up with a solid gold bracelet that she claims belonged to her dead mother, Lilly and the team re-open the 1990 case of the Cambodian immigrants who were brutally murdered in their home in what was then believed to be a robbery. When it's revealed that the dead couple hid their identity in order to evade deportation, Lilly must piece together who these people really were.
The headless torso of a woman who disappeared in 1985, on the same day she filed domestic-abuse against her husband, is found by hikers in a wildlife preserve. The investigation quickly leads to the grisly discovery of eight more decapitated bodies, the victims of a serial killer.
Lilly re-opens the 1969 case of a young woman found murdered in her lover's apartment after the victim's aggressive brother gathers more information, and finds that she has more than one prime suspect.
When drawings depicting the murder of a child from 1993 are found next to the victim's grave, the detectives re-open the case and the child's former caregiver becomes the prime suspect.
When a priest comes forward with a person's confession related to the death of a 9-year-old boy, police reopen the 1998 case, and the boy's uncle becomes a prime suspect.
When a truck containing human bones is retrieved from the Delaware River, Rush and Valens link the truck to a Prohibition bootlegger and believe the remains may be those of a woman who went missing in 1932.
The discovery of nine human skulls leads Rush back to George Marks, the serial killer she was unable to incriminate months earlier, and who walked away a free man. As the detectives reinvestigate his mother's murder from 1972, George is forced to emerge from hiding to face Rush again. This time, their very lives are at stake in their final showdown.
In 1995, two teenage boys went on a shooting spree at a local mall and committed suicide shortly afterwards. The team is prompted to re-open the case when new evidence suggests that there may have been a third shooter who got away.
The team re-opens the 2004 case of a female veteran of the Iraqi War when her prosthetic arm is found in a river. Meanwhile, Scotty visits his older brother in connection with a case that brings up painful memories from their childhood.
When the remains of a sandhog miner who disappeared in 1947 are found in a subway service tunnel, the team is prompted to re-open the case when they suspect the victim might have been murdered for being a union activist.
Lilly re-investigates a 1982 case where a newborn baby died under suspicious circumstances of what was reported as SIDS (sudden infant death syndrome).
Lilly re-opens a 2003 case in which an autistic boy's parents were shot in their car when Joseph brings her information that the boy might have seen the killer.
When new evidence of a murder case from 1979 is found, Det. Jeffries – who then worked on the case as a rookie cop – sets out to find the killer, fulfilling the promise he made to the victim's daughter 27 years ago.
When an undelivered letter with a missing child's handwriting on it shows up, the team is prompted to re-open the case of an 8-year-old girl who disappeared in 1975.
The team re-investigates the 1968 death of a policeman who was shot in his patrol car. The case was then ruled as a drug bust gone bad, but new evidence now reveals the victim may have been romantically involved with his partner.
When Jeffries' former partner comes forth with new evidence of the 2000 murder of a country singer, Lilly must travel to Knoxville, Tennessee with the reluctant Scotty in tow.
When a video clip of a missing student is found on the Internet, the team re-investigates the case of a talented 17-year-old boy who disappeared just a year before in early 2006.
In 2002, two kids were shot in front of two different schools on the same day at precisely 8:03 a.m. It's the fifth anniversary of the shootings, and Kat Miller wants to re-open the murders because she feels the cases are connected.
When traces of an explosive are found in a house, the team re-opens the 1981 case of a married couple who died in the same house in what was then ruled as an accidental gas leak.
When a body is found in a dumpster, the team re-opens the 1984 case of a murdered teenage boy who wanted to become a dancer against his father's wishes.
The plight of a homeless family living out of their station wagon becomes the cold case team's focus as they investigate the 1999 murder of a woman found at the bottom of a river.
A man claims responsibility for pushing a sex offender off a building and vows to systematically kill another person every day until the cold case team can solve his son's 1987 murder.
An anonymous confession to the killing of a 16-year-old girl in 1997 is found in a modern art exhibit, forcing the Cold Case team to enter the complicated, emotional and vicious world of high school cheerleading.
The Cold Case detectives delve into the world of the Russian mob when they re-open a 2005 case involving the murder of a longshoreman when he innocently got in the middle of a profitable human trafficking ring.
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