Gamma glutamyl transpeptidase

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gamma-glutamyltransferase 1
Identifiers
Symbol	GGT1 GGT
HUGO	4250
Entrez	2678
OMIM	231950
RefSeq	NM_001032364
UniProt	P19440
Other data
EC number	2.3.2.2
Locus	Chr. 22 q11.1-11.2

gamma-glutamyltransferase 2
Identifiers
Symbol	GGT2 GGT
HUGO	4251
Entrez	2679
OMIM	137181
RefSeq	NM_002058
UniProt	P36268
Other data
EC number	2.3.2.2
Locus	Chr. 22 q11.1-11.2

gamma-glutamyltransferase 3
Identifiers
Symbol	GGT3
HUGO	4252
Entrez	2680
Other data
EC number	2.3.2.2
Locus	Chr. 22 [1]

Gamma glutamyl transferase (GGT or GGTP, or Gamma-GT) (EC 2.3.2.2) is a liver enzyme.

Contents 1 Function 2 Location 3 Clinical significance 4 References

Function

It is involved in the transfer of amino acids across the cellular membrane and in glutathione metabolism.

Location

GGT is found in high concentrations in the liver, bile ducts and kidney.

The enzyme is also present in other tissues, such as the epididymis.

Clinical significance

Its level in the blood may be tested for, as an elevated level may indicate an abnormality in the liver, though this can be caused by a number of conditions including:

• congestive heart failure
• cholestasis (congestion of the bile ducts)
• cirrhosis of the liver
• Restricted blood flow to the liver
• Necrosis of the liver
• Liver tumors
• hepatitis
• hepatotoxic drugs

Its levels are increased in chronic and acute alcohol abuse.

References

• MedlinePlus Encyclopedia 003458

de:Gamma-Glutamyltransferase

es:Gamma glutamil transpeptidasa fr:Gamma glutamyl transpeptidase it:Gamma GT (GGT) pl:Γ-glutamylotranspeptydaza

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