Click on any series score to link to that series' page.
Higher seed had home field advantage during Division Series and League Championship Series.
The American League champion had home field advantage during the World Series as a result of the AL victory in the 2006 All-Star Game.
Gene Elston is selected to receive the Ford C. Frick Award. During his 47 years in the broadcast booth, the former Astros announcer brought a no-nonsense approach to reporting the happenings on the diamond.
March 3 - In the first-ever World Baseball Classic game, Jae Weong Seo pitches two-hit ball and Chan Ho Park works three effective innings for a save to lead South Korea past Taiwan 2–0. The first game of the 16-nation tournament starts at 11:30 a.m. local time and is played before a sparse crowd of 5,193 at Tokyo Dome. In the second game, playing before a crowd of 15,869, Tsuyoshi Nishioka and Kosuke Fukudome hit back-to-back home runs in the fifth inning to lead Japan to an 18–2 rout of China.
March 19 - After 19 seasons, two-time NL All-Star pitcher Al Leiter retires after his first 2006 spring training appearance for the Yankees.
March 20 - Japan defeats Cuba 10-6 in the championship game of the 2006 World Baseball Classic. After falling behind 6-1 early in the game, Cuba pulls back to within one run entering the ninth inning before Japan closes the door. The championship game of the first international baseball tournament open to players from Major League Baseball features teams that, combined, have only two players on a Major League roster.
March 28 - Marquis Grissom announces his retirement after a 17-year career. The MVP of the 1997 ALCS, a four-time Gold Glove winner and two-time All-Star, Grissom retires as one of seven players with 2,000 hits, 200 home runs and 400 stolen bases.
March 30 - Commissioner Bud Selig appoints Red Sox director and former U.S. Senate Majority LeaderGeorge J. Mitchell to head a probe into the use of steroids and other performance-enhancing drugs in the major leagues. The investigation is initially limited to events since September 2002, when such drugs were banned in the majors, but Mitchell has the authority to expand its scope.
In the Phillies' 4-2 loss to the Cardinals, Jimmy Rollins goes 0-4, ending his multi-season hitting streak at 38 games.
R.A. Dickey of the Rangers ties a post-1900 major league record by giving up six home runs in 3 1/3 innings in Texas' 10-6 loss to the Tigers. Dickey had converted to throwing knuckleballs the previous season, and after this game he was sent to the Rangers' AAA team to work on it. Chris Shelton led the charge with two home runs. Magglio Ordóñez also hit two home runs, but only one off Dickey.
April 9 - Cory Sullivan of the Rockies becomes only the eleventh player in major league history to triple twice in the same inning. It is the first time the feat had been accomplished in over fifty years. The two triples came against Padres pitchers Jake Peavy and Chan Ho Park.
April 10 - The Cardinals play their first official game at the New Busch Stadium, a 6-4 victory over the Brewers.
April 17 - Pedro Martínez of the Mets becomes the 103rd major league pitcher in the modern era (and the 131st overall, including the pre-1900 era) to win 200 games in his career with a 4-3 victory over the Braves at Shea Stadium.
April 22 - The Brewers hit a record-tying five home runs in the fourth inning, scoring seven runs, as they defeat the Reds 11-0. Bill Hall, Damian Miller, Brady Clark and J.J. Hardy all hit their home runs off of Brandon Claussen before the first out is recorded in the inning. Prince Fielder hits the fifth homer off of Chris Hammond with two out. Miller's and Clark's are two-run homers, while the rest are solo.
In a 6-2 victory over the Brewers, Cubs pitcher Greg Maddux earns the victory with 6 strikeouts and 2 ER over 6.0 IP, earning the first 5-0 start of his career.
Two home run records are tied or broken: Kevin Mench of the Rangers becomes the first right-handed batter in major league history to hit home runs in seven consecutive games, and Albert Pujols of the Cardinals ties a record with his 13th home run in the month of April. Mench failed to homer in his next game, falling short of tying the all-time record of eight consecutive games with a homer. Pujols would go on to break the record with 14 homers in April.
May 15 - The annual Hall of Fame Game between the Reds and the Pirates is cancelled due to rain with the Reds leading 3-0 in the third inning; it is the fifth rainout in the game's history, and the first since 1993.
May 20 — Barry Bonds ties Babe Ruth for second place on the career list, and first place among left-handed hitters, with his 714th home run during the Giants' road game against the Athletics.
May 21 - The Minnesota Legislature, on the last full day of the 2006 session, approves a new ballpark for the Minnesota Twins, scheduled to open for the 2010 season. Under the bill, the Twins are prohibited from being folded by Major League Baseball or moved from the state of Minnesota for the 30-year duration of the initial lease. The bill was signed into law by Governor Tim Pawlenty at the Twins' May 23 home game vs. the Indians.
May 24 - In the Cardinals' 10-4 victory at San Francisco, pitcher Adam Wainwright becomes the seventh player in history to hit a home run on the first major league pitch he sees.
May 27 - Curt Schilling of the Red Sox becomes the 104th major league pitcher in the modern era (and the 132nd overall, including the pre-1900 era) to win 200 games in his career with a 6-4 victory over the Devil Rays at Fenway Park.
May 28 - Barry Bonds hits his 715th career home run off Rockies pitcher Byung-Hyun Kim in a 6-3 loss at AT&T Park. With the home run, Bonds passes Babe Ruth for second place on the career list and sets a new record for home runs by a left-handed hitter.
June 6 - It is reported that U.S. federal officials have raided Diamondbacks pitcher Jason Grimsley's home looking for evidence that he was a distributor of human growth hormone and other performance-enhancing drugs. They found he had received a package. A day later he quits the Diamondbacks, and it is announced that he has given authorities names of people he knew that took steroids and HGH.
June 18 - Kenny Rogers of the Tigers becomes the 105th major league pitcher in the modern era (and the 133rd overall, including the pre-1900 era) to win 200 games in his career with a 12-3 victory over the Cubs at Wrigley Field.
June 30 - Adam Dunn hits a walk-off grand slam with 2 outs in the ninth for a 9-8 Reds victory over the Indians, becoming only the 14th player ever to hit a walk-off grand slam for a 1-run win with two out in the ninth inning.
July
July 1 - Baltimore's Miguel Tejada plays in his 1,000th consecutive game in a 7-4 win over the Braves.
Cubs outfielder Angel Pagan becomes the first player in major league history to hit his first two career home runs on his birthday with a pair of homers in a game against the White Sox at Wrigley Field.
The Twins become the first team in baseball history to collect all three monthly player awards as Joe Mauer is named Player of Month, Johan Santana earns Pitcher of the Month and Francisco Liriano is selected as Rookie of the Month for June [1].
July 4 - The Indians defeat the Yankees 19-1, the second time the Indians have routed the Yankees in significant fashion. The Indians hit 6 homers in the game and have a 9-run 5th inning. Jake Westbrook is the winner after also winning the first rout of the Yankees.
July 5 - In an 11-3 win over the Indians, Yankees starting pitcher Mike Mussina becomes the first pitcher in AL history to win 10 or more games for 15 consecutive seasons [2].
July 7 - Cleveland designated hitter Travis Hafner hits his fifth grand slam of the season in the Indians' 9-0 win over the Orioles. Hafner becomes the first player in major league history to hit five grand slams before the All-Star break [3].
July 9 - The White Sox and the Red Sox play a 19-inning game spanning 6 hours and 19 minutes at U.S. Cellular Field in Chicago. The teams use a combined 16 pitchers, who throw a combined 570 pitches. The White Sox win 6-5.
Major League Baseball announces that FOX Sports has signed on to a new seven-year contract to continue airing MLB on FOX, ensuring that the World Series will air on FOX through the 2013 season. They will also be airing their Saturday Game of the Week and alternating League Championship Series throughout the contract. TBS Sports also signs a contract that will give them 28 nationwide MLB games a year beginning in 2008, all Division Series and wild-card tiebreaker games beginning this year, and a reduction in their nationwide contract on Atlanta Braves games from 70 a year to 45 a year starting in 2008. The other LCS contract is still being negotiated at this date.
The American League wins the All-Star Game 3-2 when Michael Young hits a 2-RBI triple against Trevor Hoffman with two outs in the top of the ninth to secure the AL's ninth consecutive victory; Young also makes a fine catch of a short fly ball to end the game with the tying run on second base. Vladimir Guerrero and David Wright had exchanged home runs early in the game, with Carlos Beltrán later scoring for the NL on a wild pitch.
Jim Eriotes of the Sioux Falls Canaries becomes, at age 83, the oldest player ever to bat in a professional baseball game. A former minor league outfielder, he strikes out as the leadoff hitter, fouling off one pitch.
July 15 - For the first time since 1978, all major league games in a single day finish without a single save being recorded [5].
Cliff Floyd and Carlos Beltrán of the Mets both hit grand slams during a club-record 11-run sixth inning in a 13-7 victory over the Cubs; eight of the 11 runs are unearned following a pair of errors by Todd Walker. It is also the first time the Mets have hit two grand slams in one inning, or even an entire game. It is the first time that two grand slams were hit in one inning by a team since Fernando Tatis hit two in one inning for the Cardinals on April 23, 1999.
With a two-run home run against the Padres at Petco Park, Chipper Jones of the Braves ties a major league record with an extra base hit in his 14th straight game. The record was set in 1927 by the Pirates' Paul Waner.
Mariano Rivera of the Yankees becomes the fourth pitcher ever to record 400 saves when he pitches two shutout innings. The Yankees beat the White Sox 6-4.
July 18 - At the age of 94, former Negro League legend Buck O'Neil becomes the oldest player to play in a professional baseball game, leading off for both teams (by means of an unorthodox mid-game "trade") in the Northern League All-Star Game in Kansas City, Kansas. He is intentionally walked in both plate appearances.
July 20 - The Brooklyn Cyclones and Oneonta Tigers play the longest game in the history of the New York-Penn League with a 26-inning match, beating the previous record set in 1981 when the Batavia Muckdogs and Auburn Doubledays played for 22 innings. The Tigers defeated the Cyclones, 6-1, thanks to scoring five runs in the top of the 26th inning off Brooklyn outfielder Mark Wright, who had entered the game to pitch despite having not pitched in any games during his college career. Oneonta center fielder and leadoff hitter Deik Scram was hitless in his first 11 at-bats, but his single in the 26th inning scored the go-ahead run for the Tigers. Brooklyn manager George Greer was ejected in the first inning for arguing a call and watched the rest of the game from the clubhouse. The two teams combined used 14 pitchers, struck out 38 batters, issued 14 walks, and got 34 hits [6][7].